Six people were killed in unrest as protesters flooded Egypt's streets calling for Islamist President Mohamed Morsi to step down, the health ministry said on Monday.
Five people were killed when clashes broke out on Sunday evening and another person died overnight from injuries, a ministry official told a private satellite channel.
Some protesters had attacked the Cairo headquarters of the Muslim Brotherhood, from which Morsi hails.
Television pictures showed the building on fire as dozens of people attacked it, throwing stones and fire bombs.
Supporters of the Brotherhood fired buckshot at the attackers in a bid to repel them, an Agence France Presse journalist at the scene said. Later, automatic weapons fire could be heard around the building.
Hundreds of demonstrators spent the night in Cairo's iconic protest site Tahrir Square and outside the presidential palace, after the army estimated that millions took to the streets to call for Morsi's resignation.
Sunday's turnout, on the first anniversary of Morsi's inauguration, was described as the largest ever protest in the country's history.
"Long live the people," read the headline of the independent daily al-Tahrir, while Al-Masry al-Youm labelled Sunday's protests the "June 30 revolution".
Egypt has been deeply divided between Morsi's Islamist supporters who vowed to defend his legitimacy as the first Egyptian president elected in a free vote, while his opponents accuse him of installing an Islamist monopoly in state institutions.
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