Iran's supreme leader, Ayatollah Ali Khamenei, who crushed internal threats repeatedly during more than three decades in power, now faces his greatest challenge yet.

His archenemy, Israel, has secured free rein over Iran's skies and is decimating the country's military leadership and nuclear program with its punishing air campaign. It is also threatening his life: Israeli Defense Minister Israel Katz said Khamenei "cannot continue to exist."

Iran's foreign minister plans to meet in Geneva on Friday with leading European counterparts, who hope to open a window for a diplomatic solution to the weekold war that has seen Israeli airstrikes target Iranian nuclear and military sites and Tehran firing back.

Iranian Foreign Minister Abbas Araghchi, however, said his country is not seeking negotiations with anyone as long as Israel continues its strikes on Iran.

Israel and Iran exchanged strikes a week into their war Friday as new diplomatic efforts appeared to be underway.

Iran's Foreign Minister Abbas Araghchi appeared headed to Geneva for meetings with the European Union's top diplomat and counterparts from the United Kingdom, France and Germany. A plane with his usual call sign took off from the Turkish city of Van, near the Iranian border, flight-tracking data from FlightRadar24 showed. Iran typically acknowledges his departure hours afterward.

Iranian Foreign Minister Abbas Araghchi rejected any negotiations with the United States while Israel continues its attacks on Iran, in an interview with state TV broadcast on Friday.

"The Americans have repeatedly sent messages calling seriously for negotiations. But we have made clear that as long as the aggression does not stop, there will be no place for diplomacy and dialogue," said the chief diplomat, who was due in Geneva for talks with his European counterparts.

U.S. President Donald Trump said Thursday he will decide whether to join Israel's strikes on Iran within the next two weeks as there is still a "substantial" chance of talks to end the conflict.

Trump's move to hit the pause button could open up space for diplomacy, after days of fevered questions about whether or not he would order U.S. military action against Tehran.

The Israeli military said Thursday that Iran used a missile with multiple warheads in its attack, posing a new challenge to its defenses.

Instead of having to track one warhead, missiles with multiple warheads can pose a more difficult challenge for air defense systems, like Israel’s Iron Dome.

Locals, art lovers and diplomats like to meet over a meal and a drink in the historic Gastrobar Berlage behind a landmark art museum in The Hague.

But the usual stream of visitors turned into a trickle when fences started rising outside as part of super-tight security around a meeting of NATO leaders that is smothering the Dutch city in a massive military and police operation called Orange Shield.

Much of the focus on Iran's nuclear program has been on Tehran's enrichment of uranium, but experts also keep a close watch on the Islamic Republic's Arak heavy water reactor.

That's because the facility, some 250 kilometers (155 miles) southwest of Tehran, could produce plutonium, which can be used to make an atomic bomb.

Russia and Ukraine said Thursday they had completed another exchange of captured soldiers, part of an agreement reached earlier in June at peace talks in Istanbul.

"Our people are returning home from Russian captivity," Ukrainian President Volodymyr Zelensky said on social media, as Russia's defence ministry also confirmed the exchange. Neither side said how many soldiers had been freed.

Iran's deputy foreign minister warned the United States on Thursday against intervening in the war to back up its ally Israel, adding that his country was ready to defend itself in case of escalation.

"If the United States wants to actively enter the field in favor of the Zionist regime, Iran will have to use its tools to both teach a lesson to aggressors and defend its national security and national interests," said deputy foreign minister Kazem Gharibabadi, according to state TV.