Iran on Tuesday called on the Egyptian military to support national reconciliation and respect the "vote of the people" after it warned it was ready to intervene in Egypt's political crisis.

"Mohammed Morsi is the incumbent president based on the people's vote," Iranian deputy foreign minister Hossein Amir Abdollahian told the official IRNA news agency.

Egyptian Foreign Minister Mohammed Kamel Amr has tendered his resignation, the official MENA news agency reported on Tuesday.

Amr is the latest and most high profile minister to resign after millions of Egyptians took to the streets to demand President Mohammed Morsi step down.

U.S. President Barack Obama called President Mohamed Morsi to warn him that the voices of all Egyptians must be heard as a political crisis escalates, the White House said Tuesday.

Obama placed the call from Tanzania, on the final stop of his African tour and told him Washington was committed to "the democratic process in Egypt and does not support any single party or group," the official said.

Egypt's presidency on Tuesday rejected an army ultimatum threatening to intervene if Islamist President Mohammed Morsi did not meet the demands of the people, raising the stakes in the country's political crisis.

The army statement, read out on television Monday, had given Morsi 48 hours to comply with its call.

The United Nations warned Monday that the result of Egypt's new deadly political turmoil will have a "significant impact" on the transformation of other countries in the Middle East.

"The world is watching Egypt and what Egypt does with its transition will have a significant impact on other transition countries in the region," said deputy U.N. spokesman Eduardo del Buey as the Egyptian military gave President Mohamed Morsi 48 hours to meet popular demands.

Egypt's armed forces warned on Monday that it will intervene if the people's demands are not met within 48 hours, after millions took to the streets to demand the resignation of Islamist President Mohamed Morsi.

In a statement read out on state television, the armed forces reiterated its "call that the demands of the people be met and gives (all parties) 48 hours, as a last chance, to take responsibility for the historic circumstances the country is going through."

The Cairo-based Al-Azhar, Sunni Islam's top authority, voiced concern on Monday about the infiltration of gunmen into "peaceful" protests across Egypt demanding the resignation of Islamist President Mohammed Morsi.

"Al-Azhar is monitoring with deep concern what is happening, particularly reports of casualties and the arrest of arms smugglers who seem to have infiltrated the peaceful scene in a bid to turn their weapons on gatherings and cause further bloodshed," a statement said.

The Muslim Brotherhood has proven a failure in Egypt, Syria's Information Minister Omran al-Zohbi said on Monday, as Egyptian protesters demonstrated for a second consecutive day against Islamist President Mohamed Morsi.

"It is clear the Muslim Brotherhood is incapable... of running the state in Egypt. Their model has failed for ever," Zohbi said at a press conference broadcast by Syrian state television.

Egypt's ministers of tourism, environment, communication and legal affairs tendered their resignations on Monday a day after massive protests against President Mohamed Morsi swept the country, a senior government official told Agence France Presse.

The four handed in their letters of resignation together to Prime Minister Hisham Qandil, the official said.

Six people were killed in unrest as protesters flooded Egypt's streets calling for Islamist President Mohamed Morsi to step down, the health ministry said on Monday.

Five people were killed when clashes broke out on Sunday evening and another person died overnight from injuries, a ministry official told a private satellite channel.