The U.S. military on Sunday said three service members have been killed and five seriously wounded in the operation against Iran -- the first casualties of any kind announced on the U.S. side.

The death toll from an Iranian missile attack Sunday in the Israeli city of Beit Shemesh rose to at least nine people, first responders said, in the deadliest strike in the country since the war began.

The Magen David Adom emergency service said: "In the Beit Shemesh area, MDA EMTs and paramedics have pronounced the deaths of nine" people, as well as 28 others injured, with police saying it was a direct hit on a building.

Cheers in Tehran. Retaliation and mourning by Iran. Protests in some parts of the Muslim world, celebrations in others.

Iranian strikes and drone attacks targeted northern Iraq, where U.S. troops are deployed, as furious protests raged in Baghdad on Sunday over the killing of Iran's supreme leader Ayatollah Ali Khamenei.

France can only "be satisfied" with the killing of Iran's supreme leader Ayatollah Ali Khamenei in U.S.-Israeli strikes, said government spokeswoman Maud Bregeon on Sunday.

Israel's military said Sunday that it was "not aware" of any U.S. or Israeli strike on a school in Iran that Iranian authorities say was hit the previous day, killing over 100 people.

The Israeli military on Sunday said it had destroyed roughly half of Iran's missile stockpiles, adding the Islamic republic had been producing dozens of surface-to-surface missiles each month.

Iranian state television on Sunday confirmed the death of Iran's supreme leader Ayatollah Ali Khamenei, without referring to a massive U.S. and Israeli attack on his residence.

Israeli Prime Minister Benjamin Netanyahu said that there were signs that Iran's Supreme Leader Ayatollah Ali Khamenei had been killed in an attack on his compound as part of U.S.-Israeli strikes.

The United States and Israel launched a wave of strikes against targets in Iran on Saturday, sparking swift retaliation by the Islamic republic which responded with missile attacks across the region.