Israel announced on Wednesday a "temporary" new route for residents to flee Gaza City, as it launched an intense ground offensive after massive bombardment of the Palestinian territory's main city.

The Israeli military "announces the opening of a temporary transportation route via Salah al-Din Street", spokesman Avichay Adraee said in a statement, adding that "the route will be open for 48 hours only".

U.S. President Donald Trump said Tuesday that Hamas would be in "big trouble" if they use hostages in Gaza as human shields during a new offensive launched by Israel.

"We'll wait to hear what happens, because I hear Hamas is trying to use the old human shield deal, and if they do that they're going to be in big trouble," Trump told reporters when asked about Israel's offensive.

Syrian foreign minister Asaad al-Shaibani announced on Tuesday a plan backed by Jordan and the United States to restore calm to Druze-majority Sweida province, which witnessed deadly violence in July.

"The Syrian government has laid out a clear roadmap for action... that supports justice and builds trust," Shaibani said in a press conference, adding that the plan involves "holding accountable" those who attacked civilians, "compensating those affected", and "launching a process of internal reconciliation".

Yemen's Houthi rebels reported Israeli strikes on the country's Hodeida port on Tuesday, after Israel's military issued evacuation warnings for the area.

The rebel Al-Masirah television reported "a series of raids by Israeli enemy aircraft on the port of Hodeida", while military spokesman Yahya Saree said the group's air defenses were "currently confronting Israeli enemy aircraft launching an aggression against our country".

Palestinian residents reported heavy strikes Tuesday across Gaza City and Israel's defense minister said that "Gaza is burning" as a new Israeli ground offensive targeted the city.

Airstrikes have pounded Gaza City for some time in the lead-up to the operation, knocking down towers in the city.

Arab and Muslim leaders called for a review of ties with Israel after emergency talks in Doha on Monday following last week's deadly strike on Hamas members in the Qatari capital.

U.S. Secretary of State Marco Rubio met Qatar's leader Tuesday to ask the Gulf country to stay on as a mediator in Gaza talks, a week after Israeli warplanes attacked Hamas leaders in the emirate.

Israel launched its long anticipated ground assault on Gaza City before dawn on Tuesday, shortly after visiting U.S. Secretary of State Marco Rubio backed its goal of eradicating Hamas in Gaza.

A United Nations probe, meanwhile, charged Israel with committing "genocide" in the Palestinian territory and accused Prime Minister Benjamin Netanyahu and other top officials of incitement.

Qatar's emir said Monday that Israel had sought to derail Gaza talks by striking Hamas negotiators in his country last week, and that its premier Benjamin Netanyahu dreams of an Arab world under Israeli influence.

"Whoever works diligently and systematically to assassinate the party with whom he is negotiating, intends to thwart the negotiations... Negotiations, for them, are merely part of the war," Sheikh Tamim bin Hamad Al-Thani told Arab and Muslim leaders gathered in Doha to discuss the attack.

U.S. Secretary of State Marco Rubio said Washington would provide "unwavering support" to Israel in the war in Gaza as he called for the eradication of Hamas during a visit to the U.S. ally on Monday.