The Israeli military said it launched a fresh series of strikes Sunday targeting military targets including missile launchers in western Iran after the United States attacked the country's nuclear sites.

At least 16 people were hurt and at least one impact was reported in central Israel after Iran launched two waves of missiles at the country following the U.S. bombing of its nuclear sites, rescue services and reports said.

U.S. President Donald Trump said U.S. air strikes on Sunday "totally obliterated" Iran's main nuclear sites, as Washington joined Israel's war with Tehran in a flashpoint moment for the Middle East.

In a televised address to the nation from the White House, Trump warned that the United States would go after more targets if Iran did not make peace quickly.

Israel targeted "two centrifuge production sites" at Iran's Isfahan nuclear facility overnight in a second wave of strikes on the location since the start of the war, a military official said on Saturday.

Israel claimed on Saturday it has already set back Iran's presumed nuclear program by at least two years, a day after U.S. President Donald Trump warned that Tehran has a "maximum" of two weeks to avoid possible American air strikes.

U.S. President Donald Trump said overnight that Iran had a "maximum" of two weeks to avoid possible U.S. air strikes, indicating he could take a decision before the fortnight deadline he set a day earlier.

Hours of talks aimed at de-escalating fighting between Israel and Iran failed to produce a diplomatic breakthrough as the war entered its second week with a fresh round of strikes between the two adversaries.

At least 23 heavy Iranian missiles were fired at Israel on Friday afternoon, causing extensive damage in Tel Aviv and wounding at least 10 in Haifa, two of them seriously, after six missiles managed to penetrate Israel’s air defenses, Iranian and Israeli media reports said.

Video footage showed a missile causing a big explosion in Haifa, with Israel’s Channel 13 saying there are fears of a possible leakage of dangerous material.

Gaza's civil defense agency said Israeli forces killed at least 43 people on Friday, including 26 who had gathered near an aid distribution center, the latest in a string of deadly incidents targeting aid seekers in the Palestinian territory.

"Forty-three martyrs have fallen as a result of the ongoing Israeli bombardment on the Gaza Strip since dawn today, 26 of whom were waiting for humanitarian aid," Mohammad Al-Mughayyir, director of medical supply at the civil defense agency in Gaza, told AFP.

Israel and Iran exchanged strikes a week into their war Friday as President Donald Trump weighed U.S. military involvement and new diplomatic efforts got underway.

Trump has been weighing whether to attack Iran by striking its well-defended Fordo uranium enrichment facility, which is buried under a mountain and widely considered to be out of reach of all but America's "bunker-buster" bombs. He said he'll decide within two weeks whether the U.S. military will get directly involved in the war given the "substantial chance" for renewed negotiations over Tehran's nuclear program.