Air raid sirens sounded in the Tel Aviv area and parts of northern Israel on Tuesday, the military said, after warning of a fresh salvo of incoming missiles fired from Iran.

"A short while ago, sirens sounded in several areas across Israel following the identification of missiles launched from Iran toward the state of Israel," a statement from the military said, with residents of the Tel Aviv area and parts of the north urged to seek shelter.

Israel stunned and hobbled Iran last week when it pulled off an intelligence and military operation years in the making that struck high-level targets with precision.

Guided by spies and artificial intelligence, the Israeli military unleashed a nighttime fusillade of warplanes and armed drones smuggled into Iran to quickly incapacitate many of its air defenses and missile systems. With greater freedom to fly over Iran, Israel bombarded key nuclear sites and killed top generals and scientists. By the time Iran mustered a response hours later, its ability to retaliate — already weakened by past Israeli strikes — was greatly diminished.

There appear to have been "direct impacts" on the underground part of Iran's Natanz nuclear site during Israel's attacks, the U.N.'s atomic watchdog said on Tuesday.

"Based on continued analysis of high resolution satellite imagery collected after Friday's attacks, the IAEA has identified additional elements that indicate direct impacts on the underground enrichment halls at Natanz," the International Atomic Energy Agency said on X, formerly Twitter.

Iran has few viable options for striking back at Israel, largely because its key regional proxy Hezbollah has been "decapitated," according to Fabian Hinz of the International Institute of Strategic Studies, a London-based think tank focusing on defense and security issues.

The Houthi rebels in Yemen, another of Iran’s allies, depend on long-range Iranian missiles but supplies are limited, Hinz said.

Twenty countries denounced in a joint statement the escalating tensions in the Middle East caused by what they term Israel’s aggression against Iran and called for diplomacy and dialogue to restore stability in the region.

“There’s an imperative need to halt Israeli hostilities against Iran, which come during a time of increasing tension in the Middle East, and to work towards de-escalation, to achieve a comprehensive ceasefire and restoration of calm,” read the statement.

Iran's Revolutionary Guards said they struck a center of Mossad, Israel's foreign intelligence service, in Tel Aviv on Tuesday, amid an escalating air war between the two foes.

In a statement aired on state television, the Guards said they "struck the military intelligence centre of the Zionist regime's army, Aman, and the Zionist regime's terrorist operations planning centre, the Mossad, in Tel Aviv", adding it was "currently on fire".

After Israeli strikes landed near the hotel where he was staying in the Iranian province of Qom, Aimal Hussein desperately wanted to return home. But the 55-year-old Afghan businessman couldn't find a way, with Iranian airspace completely shut down.

He fled to Tehran after the strike Sunday, but no taxi would take him to the border as the conflict between Iran and Israel intensified.

U.S. President Donald Trump said Tuesday he was aiming for a "real end" to the conflict between arch-rivals Israel and Iran, and not just a ceasefire.

"I'm not looking for a ceasefire, we're looking at better than a ceasefire," Trump told reporters on board Air Force One before arriving back in the United States from a G7 summit in Canada.

Iran's Foreign Minister and chief nuclear negotiator Abbas Araghchi said Israel's strikes against his country "deal a blow" to diplomacy during a call Monday with his French, British, and German counterparts.

"The Israeli aggression against Iran in the midst of nuclear negotiations with the United States is a blow to diplomacy," Abbas Araghchi said during a call reported by his ministry with French Foreign Minister Jean-Noel Barrot, the United Kingdom's David Lammy, Germany's Johann Wadephul, and the European Union's head of foreign affairs Kaja Kallas.

U.S. President Donald Trump left a G7 summit in Canada a day early on Monday, heading back to the White House as Israel and Iran traded missile fire for a fifth straight day.

Trump's helicopter lifted off from the summit venue in the Canadian Rockies to take him to his plane, shortly after he warned residents to evacuate the Iranian capital Tehran.