France's Euro 2016 preparations took a knock on Tuesday with key defender Raphael Varane ruled out injured of next month's tournament on home soil with his place taken by Adil Rami.

Coach Didier Deschamps had feared the worst after Real Madrid announced Sunday that the 23-year-old Varane, capped 29 time for France, had suffered a serious left thigh injury.

Hero of Real Madrid's Champions League triumph two years ago, defender Sergio Ramos compared his first final experience to losing his virginity ahead Saturday's clash with Atletico Madrid in a rematch of the 2014 final.

Ramos broke Atletico's hearts with his stoppage time equalizer to deny Diego Simeone's men a first ever European Cup before a rampant Real ran out 4-1 winners after extra-time.

Australian Open champion Angelique Kerber crashed out in the first round of the French Open on Tuesday as the German third seed lost 6-2, 3-6, 6-3 to Kiki Bertens, the world number 58.

Bertens, who won her second career title at Nuremberg on Saturday, broke Kerber twice to claim the opening set on Court Philippe Chatrier.

Real Madrid defender Raphael Varane's chances of representing France on home soil at Euro 2016 remain in the balance after Madrid coach Zinedine Zidane confirmed he will be out for up to three weeks with a hamstring injury.

Varane will definitely miss Real's Champions League final against Atletico Madrid on Saturday and faces a race against time to be fit for France's opening Euro 2016 game against Romania on June 10.

Real Madrid coach Zinedine Zidane insisted the Champions League's top-scorer Cristiano Ronaldo will be fit for Saturday's final against Atletico Madrid despite a persistent thigh injury.

Zidane confirmed Ronaldo didn't play in a practice match on Saturday as a precaution.

Kyle Lowry and DeMar DeRozan scored more than 30 points each as the Toronto Raptors withstood a ferocious Cleveland Cavaliers fightback to level their Eastern Conference final series on Monday with a 105-99 victory.

Lowry scored 35 points while DeRozan weighed in with 32 as Toronto completed a victory that leaves the best-of-seven series tied at 2-2 with three games to play.

World number one Novak Djokovic, record nine-time champion Rafael Nadal and women's title-holder Serena Williams begin their French Open campaigns on Tuesday with the forecast far more promising after a rain-hit first two days at Roland Garros.

Three-time Roland Garros finalist Djokovic will embark on another quest to complete a career Grand Slam with Taiwan's Lu Yen-Hsun, the world number 95, his first-round opponent on Court Philippe Chatrier.

Jose Mourinho is on the verge of fulfilling his dream of managing Manchester United after Louis van Gaal's troubled two-year reign at Old Trafford came to a bitter end.

Van Gaal said he was "very disappointed" to be sacked on Monday just 48 hours after leading United to victory in the FA Cup final against Crystal Palace.

England manager Roy Hodgson defended his decision to deploy Jamie Vardy in a wide role after the Leicester City striker struck the winner in a 2-1 success against Turkey.

Vardy scored 24 goals from a central role to fire Leicester to Premier League glory this season, only to find himself lining up on the left flank in a 4-3-3 formation in Sunday's Euro 2016 warm-up match at Manchester City's Etihad Stadium.

Mario Goetze says he is looking forward to next season at Bayern Munich, dampening speculation of a move back to Borussia Dortmund, or Liverpool to work again with Jurgen Klopp.

"I am looking forward to the new season in Munich and will do everything possible to be in top shape for my first training session with Carlo Ancelotti," Goetze told German daily Bild.