Israel's massive strike on Iran on Friday morning came after decades of mutual hostility and a long-running shadow war of covert strikes and sabotage.

Israeli Prime Minister Benjamin Netanyahu has long identified Iran as its greatest threat, citing the country's nuclear program, its hostile rhetoric and support for anti-Israel militant groups across the region. Iran has championed the Palestinian cause and portrayed Israel as a malicious Western encroachment on the Middle East.

Iran's Revolutionary Guards confirmed that its aerospace commander had been killed with fellow officers in an Israeli air strike on their command center on Friday.

"Commander of the Islamic Revolutionary Guards Corps aerospace force Major General Amirali Hajizadeh... along with a group of brave and dedicated fighters of this force, were martyred" in an Israeli attack on their command center, the Guards said in a statement.

A fresh round of explosions was heard in northwestern Iran on Friday, state television reported, after Israel carried out a wave of strikes on multiple cities.

Israel launched fresh attacks on a key underground uranium enrichment facility in central Iran on Friday, Iranian state media reported.

U.S. President Donald Trump urged Iran on Friday to "make a deal," warning that there will be more "death and destruction" after Israel launched deadly strikes targeting Iranian nuclear facilities.

His comments on his Truth Social platform came after Israel pounded Iran in a series of air raids on Friday, striking 100 targets.

U.S. President Donald Trump told Fox News he was aware Israel was going to conduct strikes on Iran before it happened, and stressed that Tehran "cannot have a nuclear bomb," according to the US broadcaster.

His comments to Fox came after Israel pounded Iran in a series of air raids on Friday, striking 100 targets including nuclear and military sites.

Iran's supreme leader Ayatollah Ali Khamenei swiftly appointed new Revolutionary Guards and armed forces chiefs to replace those killed in targeted Israeli strikes on Friday.

In separate decrees, Khamenei named Mohammad Pakpour to replace Hossein Salami as commander of the Islamic Revolutionary Guard Corps, and Abdolrahim Mousavi to replace Mohammad Bagheri as chief of the armed forces general staff.

The Israeli military said it hit the underground uranium enrichment centrifuges at Iran's vast Natanz facility as part of the wave of strikes it carried out on Friday.

"The underground area of the site was damaged. This area contains a multi-storey enrichment hall with centrifuges, electrical rooms and additional supporting infrastructure," the military said in a statement.

Iran sharply criticized the UN nuclear watchdog on Friday, accusing it of "silence" over Israel's strikes on its nuclear facilities and scientists.

In a statement, Iran's Atomic Energy Organization said it considers the "silence" from the International Atomic Energy Agency "as a form of cooperation with the Zionist regime," adding that the Israeli attack was a "defeat for the IAEA resulting from its unjustifiable shortcomings".

Israel attacked Iran's capital early Friday in strikes that targeted the country's nuclear program and killed at least two top military officers, raising the potential for an all-out war between the two bitter Middle East adversaries. It appeared to be the most significant attack Iran has faced since its 1980s war with Iraq.

The strikes came amid simmering tensions over Iran's rapidly advancing nuclear program and appeared certain to trigger a reprisal, with Supreme Leader Ayatollah Ali Khamenei warning that "severe punishment" would be directed at Israel. Hours later, Israel's military said it had begun intercepting Iranian drones launched in retaliation.

U.S. President Donald Trump announced late Thursday that the U.S. remains "committed to a Diplomatic Resolution to the Iran Nuclear Issue," amid soaring tensions and reports of a possible Israeli strike on Iran's nuclear facilities.