Israel's defense ministry said Friday that Israeli air strikes across Iran had "neutralized" most of the senior leadership of the Iranian Revolutionary Guards' Air Force.

"The defense minister was informed that most of the Revolutionary Guard Air Force leadership was neutralized while convening at their underground headquarters," the ministry said in a statement.

U.S. President Donald Trump told Fox News he was aware Israel was going to conduct strikes on Iran before it happened, and stressed that Tehran "cannot have a nuclear bomb," according to the US broadcaster.

His comments to Fox came after Israel pounded Iran in a series of air raids on Friday, striking 100 targets including nuclear and military sites.

Iran's supreme leader Ayatollah Ali Khamenei swiftly appointed new Revolutionary Guards and armed forces chiefs to replace those killed in targeted Israeli strikes on Friday.

In separate decrees, Khamenei named Mohammad Pakpour to replace Hossein Salami as commander of the Islamic Revolutionary Guard Corps, and Abdolrahim Mousavi to replace Mohammad Bagheri as chief of the armed forces general staff.

The Israeli military said it hit the underground uranium enrichment centrifuges at Iran's vast Natanz facility as part of the wave of strikes it carried out on Friday.

"The underground area of the site was damaged. This area contains a multi-storey enrichment hall with centrifuges, electrical rooms and additional supporting infrastructure," the military said in a statement.

Iran sharply criticized the UN nuclear watchdog on Friday, accusing it of "silence" over Israel's strikes on its nuclear facilities and scientists.

In a statement, Iran's Atomic Energy Organization said it considers the "silence" from the International Atomic Energy Agency "as a form of cooperation with the Zionist regime," adding that the Israeli attack was a "defeat for the IAEA resulting from its unjustifiable shortcomings".

Defense Minister Israel Katz warned that Israel would "eliminate" its foes after it carried out air strikes on Iran targeting military and nuclear sites.

"The precise targeting of senior commanders of the Revolutionary Guards, the Iranian military, and nuclear scientists -- all of whom were involved in advancing the plan to destroy Israel -- sends a strong and clear message: those who work toward Israel's destruction will be eliminated," Katz said in a statement.

Jordan said it would not allow its airspace to be violated and vowed not to become a "battleground" in any regional conflict, after Israel conducted strikes on Iran on Friday.

Jordan intercepted multiple drones and missiles fired by Iran at Israel in October 2024.

Emirates airline said flights to and from Iraq, Jordan, Lebanon and Iran had been cancelled, after Israel launched strikes on Iran on Friday, sparking concerns of a wider escalation.

Several flights scheduled for Friday and one Tehran flight on Saturday were listed as cancelled on the airline's website, with the Dubai international airport also reporting that "some flights at @DXB and DWC - Al Maktoum International have been cancelled or delayed due to airspace closures over Iran, Iraq, and Syria" in a statement on X.

Israel attacked Iran's capital early Friday in strikes that targeted the country's nuclear program and killed at least two top military officers, raising the potential for an all-out war between the two bitter Middle East adversaries. It appeared to be the most significant attack Iran has faced since its 1980s war with Iraq.

The strikes came amid simmering tensions over Iran's rapidly advancing nuclear program and appeared certain to trigger a reprisal, with Supreme Leader Ayatollah Ali Khamenei warning that "severe punishment" would be directed at Israel. Hours later, Israel's military said it had begun intercepting Iranian drones launched in retaliation.

U.S. President Donald Trump announced late Thursday that the U.S. remains "committed to a Diplomatic Resolution to the Iran Nuclear Issue," amid soaring tensions and reports of a possible Israeli strike on Iran's nuclear facilities.