The U.S. military on Sunday said three service members have been killed and five seriously wounded in the operation against Iran -- the first casualties of any kind announced on the U.S. side.

Cheers in Tehran. Retaliation and mourning by Iran. Protests in some parts of the Muslim world, celebrations in others.

At least nine people were killed during pro-Iran protests at the United States consulate in the Pakistan megacity of Karachi on Sunday, according to a hospital toll seen by AFP.

France can only "be satisfied" with the killing of Iran's supreme leader Ayatollah Ali Khamenei in U.S.-Israeli strikes, said government spokeswoman Maud Bregeon on Sunday.

Britain's defense secretary said Sunday that "Iranian indiscriminate retaliatory attacks" to U.S.-Israeli strikes included "two ballistic missiles fired in the direction of Cyprus", but which were likely not "targeted" at the Mediterranean island.

Iranian state television on Sunday confirmed the death of Iran's supreme leader Ayatollah Ali Khamenei, without referring to a massive U.S. and Israeli attack on his residence.

The United States and Israel launched a wave of strikes against targets in Iran on Saturday, sparking swift retaliation by the Islamic republic which responded with missile attacks across the region.

Saudi Arabia condemned Iranian attacks targeting its neighbors in a statement released by the kingdom’s official press agency Saturday, following a flurry of salvos across the Middle East as Israel and the U.S. bombed Iran.

"The kingdom strongly condemns and denounces in the strongest terms the brutal Iranian aggression and the blatant violation of the sovereignty of the United Arab Emirates, the Kingdom of Bahrain, the State of Qatar, the State of Kuwait, and the Hashemite Kingdom of Jordan," said the statement.

U.S. President Donald Trump on Saturday announced a major attack against Iran, vowing to "annihilate" its navy and missile sites and telling Iranians their "hour of freedom" had come from the Islamic republic.

In a video address after the United States and Israel started bombing Iran, Trump made clear that the goal was sweeping –- the toppling of the Islamic republic in charge since the 1979 revolution.

The United States and Israel launched strikes against Iran on Saturday, with Israel's public broadcaster reporting that supreme leader Ayatollah Ali Khamenei had been targeted, as the Islamic republic retaliated with barrages of missiles at Gulf states and Israel.

Iran's Revolutionary Guards, the ideological arm of the Islamic republic, said they had targeted the US Fifth Fleet in Bahrain, other American interests in the Gulf and Israel.