A suspected chemical attack in Syria's Eastern Ghouta sparked international outrage Sunday, as state media reported that the last rebel holdouts in the onetime opposition stronghold had agreed to evacuate.

State news agency SANA, citing a government source, said fighters with the Jaish al-Islam rebel faction had agreed to leave Eastern Ghouta's main town of Douma within 48 hours.

Eastern Ghouta's six-year rebel rule was in its dying moments Friday as fighters evacuated one of the Syrian enclave's three remaining pockets and a deal was reached for another.

At least 20 civilians have died in a resumption of bombing on Douma, the largest town in shrinking rebel-controlled pockets of Syria's Eastern Ghouta, a monitor said Monday. 

Children are at more risk than ever in Syria's devastating conflict, the United Nations said Monday as the war approached its eighth year.

The International Committee of the Red Cross asked Wednesday for access to an enclave near Syria's capital where a regime aerial campaign has killed over 300 civilians and wounded 1,400 others this week.

U.N. Secretary-General Antonio Guterres on Tuesday said he was "deeply alarmed" by the escalating violence in Syria's Eastern Ghouta enclave after more than 100 civilians were killed in the second straight day of air strikes.

The United States has urged Russia to use its leverage over Syrian President Bashar al-Assad to end the war as the U.N. envoy warned of a "worrying and dangerous" moment in the nearly seven-year conflict.

Fresh regime strikes killed 15 civilians Wednesday in a rebel-held enclave near Damascus where overwhelmed medics were still treating the survivors of the Syrian conflict's bloodiest day in months.

The shabby, mud-covered tent in northwest Syria is the only home Abu Khaled's family has left. Uprooted four times in six years, they say war is practically stalking them.

Fresh regime strikes on a besieged rebel-held enclave near Damascus killed 47 civilians on Tuesday despite mounting Western pressure on Syrian President Bashar al-Assad.

The bloodshed came a day after another 31 civilians were killed in Eastern Ghouta and as the United Nations pleaded for a truce in the seven-year-old war to allow for aid deliveries.