The U.S. military on Sunday said three service members have been killed and five seriously wounded in the operation against Iran -- the first casualties of any kind announced on the U.S. side.

U.S. President Donald Trump on Sunday said he would "be talking" to Iranian leaders but was vague on the timing and noted that much of the country's leadership was dead.

Cheers in Tehran. Retaliation and mourning by Iran. Protests in some parts of the Muslim world, celebrations in others.

At least nine people were killed during pro-Iran protests at the United States consulate in the Pakistan megacity of Karachi on Sunday, according to a hospital toll seen by AFP.

France can only "be satisfied" with the killing of Iran's supreme leader Ayatollah Ali Khamenei in U.S.-Israeli strikes, said government spokeswoman Maud Bregeon on Sunday.

Britain's defense secretary said Sunday that "Iranian indiscriminate retaliatory attacks" to U.S.-Israeli strikes included "two ballistic missiles fired in the direction of Cyprus", but which were likely not "targeted" at the Mediterranean island.

Iranian state television confirmed the death of its supreme leader Ayatollah Ali Khamenei and launched a fresh wave of attacks on Sunday as Israel hit back at the capital Tehran.

Iranian state television on Sunday confirmed the death of Iran's supreme leader Ayatollah Ali Khamenei, without referring to a massive U.S. and Israeli attack on his residence.

The United States and Israel launched a wave of strikes against targets in Iran on Saturday, sparking swift retaliation by the Islamic republic which responded with missile attacks across the region.

Saudi Arabia condemned Iranian attacks targeting its neighbors in a statement released by the kingdom’s official press agency Saturday, following a flurry of salvos across the Middle East as Israel and the U.S. bombed Iran.

"The kingdom strongly condemns and denounces in the strongest terms the brutal Iranian aggression and the blatant violation of the sovereignty of the United Arab Emirates, the Kingdom of Bahrain, the State of Qatar, the State of Kuwait, and the Hashemite Kingdom of Jordan," said the statement.